The aging immune system: primer and prospectus
RA Miller - Science, 1996 - science.org
Science, 1996•science.org
Changes in T lymphocyte populations underlie much of the age-related decline in the
protective immune response. Aging leads to the replacement of virgin T cells by memory T
cells and to the accumulation of cells with signal transduction defects. Studies of antibody
gene assembly, accessory cell function, post-thymic T cell development, skewed selection of
T cell receptor repertoire, and the clinical concomitants of immune senescence will shed
new light on the causes and consequences of age-dependent immune failure.
protective immune response. Aging leads to the replacement of virgin T cells by memory T
cells and to the accumulation of cells with signal transduction defects. Studies of antibody
gene assembly, accessory cell function, post-thymic T cell development, skewed selection of
T cell receptor repertoire, and the clinical concomitants of immune senescence will shed
new light on the causes and consequences of age-dependent immune failure.
Changes in T lymphocyte populations underlie much of the age-related decline in the protective immune response. Aging leads to the replacement of virgin T cells by memory T cells and to the accumulation of cells with signal transduction defects. Studies of antibody gene assembly, accessory cell function, post-thymic T cell development, skewed selection of T cell receptor repertoire, and the clinical concomitants of immune senescence will shed new light on the causes and consequences of age-dependent immune failure.
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