[HTML][HTML] The apple polyphenol phloretin inhibits breast cancer cell migration and proliferation via inhibition of signals by type 2 glucose transporter
KH Wu, CT Ho, ZF Chen, LC Chen… - journal of food and drug …, 2018 - Elsevier
Human triple-negative breast cancer (TNBC) is the most aggressive and poorly understood
subclass of breast cancer. Glucose transporters (GLUTs) are required for glucose uptake in
malignant cancer cells and are ideal targets for cancer therapy. To determine whether the
inhibition of GLUTs could be used in TNBC cell therapy, the apple polyphenol phloretin (Ph)
was used as a specific antagonist of GLUT2 protein function in human TNBC cells.
Interestingly, we found that Ph (10–150 μM, for 24 h) inhibited cell growth and arrested the …
subclass of breast cancer. Glucose transporters (GLUTs) are required for glucose uptake in
malignant cancer cells and are ideal targets for cancer therapy. To determine whether the
inhibition of GLUTs could be used in TNBC cell therapy, the apple polyphenol phloretin (Ph)
was used as a specific antagonist of GLUT2 protein function in human TNBC cells.
Interestingly, we found that Ph (10–150 μM, for 24 h) inhibited cell growth and arrested the …
The apple polyphenol phloretin inhibits breast cancer cell migration and proliferation via inhibition of signals by type 2 glucose transporter.
WKH Wu KuanHsun, HCT Ho ChiTang… - 2018 - cabidigitallibrary.org
Human triple-negative breast cancer (TNBC) is the most aggressive and poorly understood
subclass of breast cancer. Glucose transporters (GLUTs) are required for glucose uptake in
malignant cancer cells and are ideal targets for cancer therapy. To determine whether the
inhibition of GLUTs could be used in TNBC cell therapy, the apple polyphenol phloretin (Ph)
was used as a specific antagonist of GLUT2 protein function in human TNBC cells.
Interestingly, we found that Ph (10-150 µM, for 24 h) inhibited cell growth and arrested the …
subclass of breast cancer. Glucose transporters (GLUTs) are required for glucose uptake in
malignant cancer cells and are ideal targets for cancer therapy. To determine whether the
inhibition of GLUTs could be used in TNBC cell therapy, the apple polyphenol phloretin (Ph)
was used as a specific antagonist of GLUT2 protein function in human TNBC cells.
Interestingly, we found that Ph (10-150 µM, for 24 h) inhibited cell growth and arrested the …
以上显示的是最相近的搜索结果。 查看全部搜索结果