The association between Zika virus infection and microcephaly in Brazil 2015–2017: An observational analysis of over 4 million births
Background In 2015, high rates of microcephaly were reported in Northeast Brazil following
the first South American Zika virus (ZIKV) outbreak. Reported microcephaly rates in other
Zika-affected areas were significantly lower, suggesting alternate causes or the involvement
of arboviral cofactors in exacerbating microcephaly rates. Methods and findings We merged
data from multiple national reporting databases in Brazil to estimate exposure to 9 known or
hypothesized causes of microcephaly for every pregnancy nationwide since the beginning …
the first South American Zika virus (ZIKV) outbreak. Reported microcephaly rates in other
Zika-affected areas were significantly lower, suggesting alternate causes or the involvement
of arboviral cofactors in exacerbating microcephaly rates. Methods and findings We merged
data from multiple national reporting databases in Brazil to estimate exposure to 9 known or
hypothesized causes of microcephaly for every pregnancy nationwide since the beginning …
The association between Zika virus infection and microcephaly in Brazil 2015-2017
Background In 2015, high rates of microcephaly were reported in Northeast Brazil following
the first South American Zika virus (ZIKV) outbreak. Reported microcephaly rates in other
Zika-affected areas were significantly lower, suggesting alternate causes or the involvement
of arboviral cofactors in exacerbating microcephaly rates. Methods and findings We merged
data from multiple national reporting databases in Brazil to estimate exposure to 9 known or
hypothesized causes of microcephaly for every pregnancy nationwide since the beginning …
the first South American Zika virus (ZIKV) outbreak. Reported microcephaly rates in other
Zika-affected areas were significantly lower, suggesting alternate causes or the involvement
of arboviral cofactors in exacerbating microcephaly rates. Methods and findings We merged
data from multiple national reporting databases in Brazil to estimate exposure to 9 known or
hypothesized causes of microcephaly for every pregnancy nationwide since the beginning …
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