The binding of NCAM to FGFR1 induces a specific cellular response mediated by receptor trafficking
C Francavilla, P Cattaneo, V Berezin, E Bock… - Journal of cell …, 2009 - rupress.org
Neural cell adhesion molecule (NCAM) associates with fibroblast growth factor (FGF)
receptor-1 (FGFR1). However, the biological significance of this interaction remains largely
elusive. In this study, we show that NCAM induces a specific, FGFR1-mediated cellular
response that is remarkably different from that elicited by FGF-2. In contrast to FGF-induced
degradation of endocytic FGFR1, NCAM promotes the stabilization of the receptor, which is
recycled to the cell surface in a Rab11-and Src-dependent manner. In turn, FGFR1 recycling …
receptor-1 (FGFR1). However, the biological significance of this interaction remains largely
elusive. In this study, we show that NCAM induces a specific, FGFR1-mediated cellular
response that is remarkably different from that elicited by FGF-2. In contrast to FGF-induced
degradation of endocytic FGFR1, NCAM promotes the stabilization of the receptor, which is
recycled to the cell surface in a Rab11-and Src-dependent manner. In turn, FGFR1 recycling …
Correction: The binding of NCAM to FGFR1 induces a specific cellular response mediated by receptor trafficking
C Francavilla, P Cattaneo, V Berezin, E Bock… - Journal of Cell …, 2019 - rupress.org
Following publication, the authors realized that Fig. 6 A inadvertently contained an incorrect
image for the 30-min treatment with FGL in the presence of SU6656 (in the “–acid wash”
condition). The image has now been replaced with the correct one (Fig. 6 A below),
corresponding to that treatment condition. This correction does not change the conclusions
of the experiment, namely, that little or no localization of HA-FGFR1 on the cell surface was
detected upon treatment with either FGF2 or FGL upon Src inhibition. The authors regret any …
image for the 30-min treatment with FGL in the presence of SU6656 (in the “–acid wash”
condition). The image has now been replaced with the correct one (Fig. 6 A below),
corresponding to that treatment condition. This correction does not change the conclusions
of the experiment, namely, that little or no localization of HA-FGFR1 on the cell surface was
detected upon treatment with either FGF2 or FGL upon Src inhibition. The authors regret any …
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