Nociceptors are a subset of small primary afferent neurons that respond to noxious
chemical, thermal and mechanical stimuli. Ion channels in nociceptors respond differently to
noxious stimuli and generate electrical signals in different ways. Anoctamin 1 (ANO1 also
known as TMEM16A) is a Ca 2+-activated chloride channel that is essential for numerous
physiological functions. We found that ANO1 was activated by temperatures over 44 C with
steep heat sensitivity. ANO1 was expressed in small sensory neurons and was highly …

The Calcium-Activated Chloride Channel Anoctamin 1 Acts as a Heat Sensor in Nociceptive
Neurons - 학지사ㆍ교보문고 스콜라 … (2012년) The Calcium-Activated Chloride Channel
Anoctamin 1 Acts as a Heat Sensor in Nociceptive Neurons … The Calcium-Activated
Chloride Channel Anoctamin 1 Acts as a Heat Sensor in Nociceptive Neurons …