The cannabinoid anticonvulsant effect on pentylenetetrazole-induced seizure is potentiated by ultra-low dose naltrexone in mice
A Bahremand, H Shafaroodi, M Ghasemi… - Epilepsy research, 2008 - Elsevier
Cannabinoid compounds are anticonvulsant since they have inhibitory effects at micromolar
doses, which are mediated by activated receptors coupling to Gi/o proteins. Surprisingly,
both the analgesic and anticonvulsant effects of opioids are enhanced by ultra-low doses
(nanomolar to picomolar) of the opioid antagonist naltrexone and as opioid and cannabinoid
systems interact, it has been shown that ultra-low dose naltrexone also enhances
cannabinoid-induced antinociception. Thus, concerning the seizure modulating properties of …
doses, which are mediated by activated receptors coupling to Gi/o proteins. Surprisingly,
both the analgesic and anticonvulsant effects of opioids are enhanced by ultra-low doses
(nanomolar to picomolar) of the opioid antagonist naltrexone and as opioid and cannabinoid
systems interact, it has been shown that ultra-low dose naltrexone also enhances
cannabinoid-induced antinociception. Thus, concerning the seizure modulating properties of …