The contribution of co-transcriptional RNA: DNA hybrid structures to DNA damage and genome instability
S Hamperl, KA Cimprich - DNA repair, 2014 - Elsevier
Accurate DNA replication and DNA repair are crucial for the maintenance of genome
stability, and it is generally accepted that failure of these processes is a major source of DNA
damage in cells. Intriguingly, recent evidence suggests that DNA damage is more likely to
occur at genomic loci with high transcriptional activity. Furthermore, loss of certain RNA
processing factors in eukaryotic cells is associated with increased formation of co-
transcriptional RNA: DNA hybrid structures known as R-loops, resulting in double-strand …
stability, and it is generally accepted that failure of these processes is a major source of DNA
damage in cells. Intriguingly, recent evidence suggests that DNA damage is more likely to
occur at genomic loci with high transcriptional activity. Furthermore, loss of certain RNA
processing factors in eukaryotic cells is associated with increased formation of co-
transcriptional RNA: DNA hybrid structures known as R-loops, resulting in double-strand …
以上显示的是最相近的搜索结果。 查看全部搜索结果