The development of hypertension and hyperaldosteronism in a rodent model of life-long obesity
CA Northcott, GD Fink, H Garver, JR Haywood… - …, 2012 - academic.oup.com
… Recent studies suggest that hyperaldosteronism should also be included in this list of …
incidence of obesity increases it is important that we develop and characterize animal models that …
incidence of obesity increases it is important that we develop and characterize animal models that …
[引用][C] The Development of Hypertension and Hyperaldosteronism in a Rodent Model of Life-Long Obesity
TS TRANSLATIONALHIGHLIGH - Endocrine Reviews, 2012 - academic.oup.com
… In addition, fat depots of DHT-treated mice displayed an … 0.001), and DHT-treated mice were
glucose intolerant (P … In conclusion, a mouse model of PCOS has been developed showing …
glucose intolerant (P … In conclusion, a mouse model of PCOS has been developed showing …
[引用][C] The Development of Hypertension and Hyperaldosteronism in a Rodent Model of Life-Long Obesity
TS TRANSLATIONALHIGHLIGH - academic.oup.com
… In addition, fat depots of DHT-treated mice displayed an … 0.001), and DHT-treated mice were
glucose intolerant (P … In conclusion, a mouse model of PCOS has been developed showing …
glucose intolerant (P … In conclusion, a mouse model of PCOS has been developed showing …
Animal models in obesity and hypertension
G Segal-Lieberman, T Rosenthal - Current hypertension reports, 2013 - Springer
… db/db mice that lack the leptin receptor do develop hypertension as well as other signs of
increased sympathetic activation [16], similar to what is seen in obese … in these models that is …
increased sympathetic activation [16], similar to what is seen in obese … in these models that is …
Aldosterone antagonism attenuates obesity-induced hypertension and glomerular hyperfiltration
RB de Paula, AA da Silva, JE Hall - Hypertension, 2004 - Am Heart Assoc
… C obese dogs. … hypertension associated with chronic dietary-induced obesity. These
observations indicate that ALDO plays an important role in the pathogenesis of obesity hypertension…
observations indicate that ALDO plays an important role in the pathogenesis of obesity hypertension…
Development of hypertension in a rat model of diet-induced obesity
AD Dobrian, MJ Davies, RL Prewitt, TJ Lauterio - Hypertension, 2000 - Am Heart Assoc
… In contrast, diet-induced obese animal models appear to be the most relevant with … obesity
model in the rat 7 19 that displays some of the characteristics of human obesity hypertension, …
model in the rat 7 19 that displays some of the characteristics of human obesity hypertension, …
Narrative review: the emerging clinical implications of the role of aldosterone in the metabolic syndrome and resistant hypertension
JR Sowers, A Whaley-Connell… - Annals of internal …, 2009 - acpjournals.org
… Obesity, insulin resistance, and hypertension commonly cluster … aldosteronism in
individuals with resistant hypertension, … muscle glucose uptake in a rodent model of renin–angiotensin–…
individuals with resistant hypertension, … muscle glucose uptake in a rodent model of renin–angiotensin–…
Mineralocorticoid receptor antagonism prevents obesity‐induced cerebral artery remodeling and reduces white matter injury in rats
PW Pires, JL McClain, SF Hayoz… - …, 2018 - Wiley Online Library
… gain and dementia, we developed a rodent model that is analogous to an … life-long obesity
in the mesenteric vasculature.28 Hyperaldosteronism has been reported in overweight/obese …
in the mesenteric vasculature.28 Hyperaldosteronism has been reported in overweight/obese …
Mineralocorticoid receptor in adipocytes and macrophages: a promising target to fight metabolic syndrome
V Marzolla, A Armani, A Feraco, MU De Martino… - Steroids, 2014 - Elsevier
… model of life-long obesity in rodents, where exposure to HF diet from weaning leads to
hypertension and hyperaldosteronism [… , in mouse models of genetic or diet-induced obesity, MR …
hypertension and hyperaldosteronism [… , in mouse models of genetic or diet-induced obesity, MR …
Translational Highlights
CS Achard, DR Laybutt - 2012 - Springer
… in a Rodent Model of Life-Long Obesity … be increased in rats with obesity-induced hypertension.
Male Sprague … be a useful model for studying obesity-associated hyperaldosteronism. …
Male Sprague … be a useful model for studying obesity-associated hyperaldosteronism. …