The development of hypertension and hyperaldosteronism in a rodent model of life-long obesity

CA Northcott, GD Fink, H Garver, JR Haywood… - …, 2012 - academic.oup.com
… Recent studies suggest that hyperaldosteronism should also be included in this list of …
incidence of obesity increases it is important that we develop and characterize animal models that …

[引用][C] The Development of Hypertension and Hyperaldosteronism in a Rodent Model of Life-Long Obesity

TS TRANSLATIONALHIGHLIGH - Endocrine Reviews, 2012 - academic.oup.com
… In addition, fat depots of DHT-treated mice displayed an … 0.001), and DHT-treated mice were
glucose intolerant (P … In conclusion, a mouse model of PCOS has been developed showing …

[引用][C] The Development of Hypertension and Hyperaldosteronism in a Rodent Model of Life-Long Obesity

TS TRANSLATIONALHIGHLIGH - academic.oup.com
… In addition, fat depots of DHT-treated mice displayed an … 0.001), and DHT-treated mice were
glucose intolerant (P … In conclusion, a mouse model of PCOS has been developed showing …

Animal models in obesity and hypertension

G Segal-Lieberman, T Rosenthal - Current hypertension reports, 2013 - Springer
… db/db mice that lack the leptin receptor do develop hypertension as well as other signs of
increased sympathetic activation [16], similar to what is seen in obese … in these models that is …

Aldosterone antagonism attenuates obesity-induced hypertension and glomerular hyperfiltration

RB de Paula, AA da Silva, JE Hall - Hypertension, 2004 - Am Heart Assoc
… C obese dogs. … hypertension associated with chronic dietary-induced obesity. These
observations indicate that ALDO plays an important role in the pathogenesis of obesity hypertension

Development of hypertension in a rat model of diet-induced obesity

AD Dobrian, MJ Davies, RL Prewitt, TJ Lauterio - Hypertension, 2000 - Am Heart Assoc
… In contrast, diet-induced obese animal models appear to be the most relevant with … obesity
model in the rat 7 19 that displays some of the characteristics of human obesity hypertension, …

Narrative review: the emerging clinical implications of the role of aldosterone in the metabolic syndrome and resistant hypertension

JR Sowers, A Whaley-Connell… - Annals of internal …, 2009 - acpjournals.org
Obesity, insulin resistance, and hypertension commonly cluster … aldosteronism in
individuals with resistant hypertension, … muscle glucose uptake in a rodent model of renin–angiotensin–…

Mineralocorticoid receptor antagonism prevents obesity‐induced cerebral artery remodeling and reduces white matter injury in rats

PW Pires, JL McClain, SF Hayoz… - …, 2018 - Wiley Online Library
… gain and dementia, we developed a rodent model that is analogous to an … life-long obesity
in the mesenteric vasculature.28 Hyperaldosteronism has been reported in overweight/obese

Mineralocorticoid receptor in adipocytes and macrophages: a promising target to fight metabolic syndrome

V Marzolla, A Armani, A Feraco, MU De Martino… - Steroids, 2014 - Elsevier
model of life-long obesity in rodents, where exposure to HF diet from weaning leads to
hypertension and hyperaldosteronism [… , in mouse models of genetic or diet-induced obesity, MR …

Translational Highlights

CS Achard, DR Laybutt - 2012 - Springer
… in a Rodent Model of Life-Long Obesity … be increased in rats with obesity-induced hypertension.
Male Sprague … be a useful model for studying obesity-associated hyperaldosteronism. …