The effect of MDR1 (ABCB1) polymorphism on the pharmacokinetic of tacrolimus in Turkish renal transplant recipients
There is marked interindividual variability in trough blood levels of tacrolimus (TRL)
following standard dosing. TRL is a substrate for P-glycoprotein (P-gp), the product of the
multidrug resistance-1 (MDR1)(ABCB1) gene. P-gp acts as a membrane efflux pump, which
affects TRL absorption from the gut. Some of the single nucleotide polymorphisms (SNP) of
ABCB1 gene are associated with pharmacokinetic characteristics of TRL. The objective of
this study was to determine the role of ABCB1 C3435T polymorphism on TRL dose …
following standard dosing. TRL is a substrate for P-glycoprotein (P-gp), the product of the
multidrug resistance-1 (MDR1)(ABCB1) gene. P-gp acts as a membrane efflux pump, which
affects TRL absorption from the gut. Some of the single nucleotide polymorphisms (SNP) of
ABCB1 gene are associated with pharmacokinetic characteristics of TRL. The objective of
this study was to determine the role of ABCB1 C3435T polymorphism on TRL dose …
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