Rotary draw tube bending is one of the most complex tube forming processes subject to different process parameters such as material properties and geometry. This process is being practiced in more and more applications in industry due to its high efficiency, high forming precision and quality. However, improper process parameters can lead to wrinkling which restrict the thin walled tube bending. Therefore, the prediction and prevention of wrinkling is very important. Despite its importance, the effect of anisotropy on the occurrence of wrinkling was not considered in the literature up to now. In this investigation, a quantitative study on the wrinkling of thin walled tube bending is carried out through a finite element model of the process using velocity integral parameter, which is used for the detection of wrinkles. The other methods usually warn the wrinkling initiation with no precise location prediction. In addition, the effects of some process parameters, specially normal and planar anisotropy on the tube wrinkling are investigated. It is shown that increasing normal and planar anisotropy (increasing r0 and r90 values) result in a decrease in tube wrinkling.