The effect of genotype on sensitivity to inflammatory nociception: characterization of resistant (A/J) and sensitive (C57BL/6J) inbred mouse strains
JS Mogil, CA Lichtensteiger, SG Wilson - Pain, 1998 - Elsevier
The important role of genetic factors in the mediation of sensitivity to pain and pain inhibition
is being increasingly appreciated. In an attempt to systematically study the genotypic
influences on inflammatory nociception, we conducted a survey of the nociceptive
responsivity of three common outbred mouse strains and 11 inbred mouse strains on the
formalin test. The formalin test is known to display a biphasic temporal pattern of behavioral
and electrophysiological activity, defined by an acute/early phase and a tonic/late phase …
is being increasingly appreciated. In an attempt to systematically study the genotypic
influences on inflammatory nociception, we conducted a survey of the nociceptive
responsivity of three common outbred mouse strains and 11 inbred mouse strains on the
formalin test. The formalin test is known to display a biphasic temporal pattern of behavioral
and electrophysiological activity, defined by an acute/early phase and a tonic/late phase …
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