Folate and its synthetic form, folic acid (FA), are essential vitamins for the regeneration of S-
adenosyl methionine molecules, thereby maintaining adequate cellular methylation. The
deregulation of DNA methylation is a contributing factor to carcinogenesis, as alterations in
genetic methylation may contribute to stem cell reprogramming and dedifferentiation
processes that lead to a cancer stem cell (CSC) phenotype. Here, we investigate the
potential effects of FA exposure on DNA methylation and colonosphere formation in cultured …

Folate and its synthetic form, folic acid, is an essential vitamin for the regeneration of S-
adenosyl methionine molecules, thereby maintaining adequate cellular methylation. The
deregulation of DNA methylation is a contributing factor to carcinogenesis, as alterations in
genetic methylation may contribute to stem cell reprograming and dedifferentiation
processes that lead to a cancer stem cell phenotype. Here, we investigate the potential
effects of folic acid exposure on DNA methylation and colonosphere formation, in cultured …