The effects of probiotic supplements on blood markers of endotoxin and lipid peroxidation in patients undergoing gastric bypass surgery; a randomized, double-blind …
Obesity surgery, 2019•Springer
Background The effect of probiotic supplements among subjects undergoing bariatric
surgery indicates conflicting results. Moreover, whether these effects remain after ceasing
the treatment remained to be elucidated. This study was conducted to assess the effect of
probiotic supplements on blood markers of endotoxin (lipopolysaccharides-binding protein:
LBP), inflammation and lipid peroxidation (malondialdehyde: MDA) in patients with morbid
obesity undergoing the one-anastomosis gastric bypass (OAGB). Methods This study is a …
surgery indicates conflicting results. Moreover, whether these effects remain after ceasing
the treatment remained to be elucidated. This study was conducted to assess the effect of
probiotic supplements on blood markers of endotoxin (lipopolysaccharides-binding protein:
LBP), inflammation and lipid peroxidation (malondialdehyde: MDA) in patients with morbid
obesity undergoing the one-anastomosis gastric bypass (OAGB). Methods This study is a …
Background
The effect of probiotic supplements among subjects undergoing bariatric surgery indicates conflicting results. Moreover, whether these effects remain after ceasing the treatment remained to be elucidated. This study was conducted to assess the effect of probiotic supplements on blood markers of endotoxin (lipopolysaccharides-binding protein: LBP), inflammation and lipid peroxidation (malondialdehyde: MDA) in patients with morbid obesity undergoing the one-anastomosis gastric bypass (OAGB).
Methods
This study is a placebo-controlled, double-blind, and randomized clinical trial and 9 months of additional follow-up. Forty-six morbid obese patients undergoing OAGB were randomized to 4 months of probiotic or placebo supplements. Anthropometric indices and blood concentration of LBP, inflammatory markers, MDA, vitamin D3, and B12 were measured at 0, 4, and 13 months of study.
Results
Probiotic supplements could improve serum LBP (P = 0.039), TNF-α (P = 0.005), vitamin B12 (P = 0.03), vitamin D3 (P = 0.001), and weight loss (P = 0.01) at month 4 in comparison to placebo; however, only serum MDA concentrations decreased significantly in the probiotic group compared with those in the placebo group (P = 0.013) at the end of follow-up period.
Discussion
It was observed that 4 months probiotic supplementation compared with placebo prohibited an elevation in the LBP levels and improved serum TNF-α and 25-OH vitamin D3 concentrations and weight loss in patients undergoing the OAGB surgery. However, these effects did not persist 9 months after the cessation of the treatment. Further investigations are required to find how long supplementation and which dosage of it can benefit body status for the long-term.
Trial Registration
This study has been registered at Clinicaltrial.gov with registration number NCT02708589 .
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