The effects of thymoquinone and genistein treatment on telomerase activity, apoptosis, angiogenesis, and survival in thyroid cancer cell lines
Aims: This study was aimed to determine the effects of thymoquinone (TQ) and genistein
(Gen) phytotherapeutics on telomerase activity, angiogenesis, and apoptosis in follicular
and anaplastic thyroid cancer cells (TCCs). Materials and Methods: Cell viability, caspase-3
(CASP-3) activity, and messenger RNA (mRNA) expression levels of human telomerase
reverse transcriptase (hTERT), phosphatase and tensin homolog (PTEN), nuclear factor-
kappa B (NF-kB), cyclin-dependent kinase inhibitor 1 (p21), and vascular endothelial growth …
(Gen) phytotherapeutics on telomerase activity, angiogenesis, and apoptosis in follicular
and anaplastic thyroid cancer cells (TCCs). Materials and Methods: Cell viability, caspase-3
(CASP-3) activity, and messenger RNA (mRNA) expression levels of human telomerase
reverse transcriptase (hTERT), phosphatase and tensin homolog (PTEN), nuclear factor-
kappa B (NF-kB), cyclin-dependent kinase inhibitor 1 (p21), and vascular endothelial growth …
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