Viral immune evasion by sequence variation is a major hindrance to HIV-1 vaccine design.
To address this challenge, our group has developed a computational model, rooted in
physics, that aims to predict the fitness landscape of HIV-1 proteins in order to design
vaccine immunogens that lead to impaired viral fitness, thus blocking viable escape routes.
Here, we advance the computational models to address previous limitations, and directly
test model predictions against in vitro fitness measurements of HIV-1 strains containing …

Viral immune evasion by sequence variation is a major hindrance to HIV-1 vaccine design.
To address this challenge, our group has developed a computational model, rooted in
physics, that aims to predict the fitness landscape of HIV-1 proteins in order to design
vaccine immunogens that lead to impaired viral fitness, thus blocking viable escape routes.
Here, we advance the computational models to address previous limitations, and directly
test model predictions against in vitro fitness measurements of HIV-1 strains containing …