The genetic architecture of common traits, including the number, frequency, and effect sizes
of inherited variants that contribute to individual risk, has been long debated. Genome-wide …

… We are in the midst of a worldwide epidemic of type 2 diabetes, obesity… genes and environment.
For decades, investigators have worked to unravel the role of genetics in type 2 diabetes …

… Most genetic variants associated with T2D are common variants with … genetic component
of T2D can be explained by common variants relies upon the shape of the genetic architecture …

… have been implicated in both monogenic and polygenic diabetes (8). A recent simulation
study evaluated genetic architectures for consistency with results from T2D genetic studies and …

… genetic architecture has important consequences for understanding the pathophysiology of
type 2 diabetes, both … this new genetic information into more effective patient management. …

… Therefore, to extend understanding of the genetic architecture and molecular basis of
T2DM, the authors conducted a meta-analysis (34 840 cases and 114 981 controls) of genetic …

… Our results have several implications regarding the genetic architecture of T2D. First, fine-mapping
suggests that currently known loci explain more of the risk than previously estimated. …

… In the MGB Biobank, type 2 diabetes was defined according to … type 2 diabetes, we excluded
control subjects younger than 55 years, because the mean age of onset for type 2 diabetes …

To date, 68 loci have been associated with type 2 diabetes (T2D) or glucose homeostasis
traits. We report here the results of experiments aimed at functionally characterizing the SNPs …

… However, the genetic architecture determines our response to the environment. Genetic
variants could affect specific metabolic processes to make an individual more susceptible to the …