The human ortholog of acid-sensing ion channel gene ASIC1a is associated with panic disorder and amygdala structure and function
Background Individuals with panic disorder (PD) exhibit a hypersensitivity to inhaled carbon
dioxide, possibly reflecting a lowered threshold for sensing signals of suffocation. Animal
studies have shown that carbon dioxide–mediated fear behavior depends on chemosensing
of acidosis in the amygdala via the acid-sensing ion channel ASIC1a. We examined whether
the human ortholog of the ASIC1a gene, ACCN2, is associated with the presence of PD and
with amygdala structure and function. Methods We conducted a case-control analysis (n …
dioxide, possibly reflecting a lowered threshold for sensing signals of suffocation. Animal
studies have shown that carbon dioxide–mediated fear behavior depends on chemosensing
of acidosis in the amygdala via the acid-sensing ion channel ASIC1a. We examined whether
the human ortholog of the ASIC1a gene, ACCN2, is associated with the presence of PD and
with amygdala structure and function. Methods We conducted a case-control analysis (n …
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