… paid to the role that the hepatic immune niche has in liver homeostasis, … is the main focus
of this review. Figure 1 summarizes the types of immune cells that have been described in the …

… in the liver promotes immune tolerance. To elucidate the role of sGRP78 in the hepatic
pre-metastatic niche, we established an experimental liver metastasis model using sGRP78-…

… Circulating and bone marrow–derived immune cells are also recruited to the liver in … of
the role of the liver microenvironment in the growth of hepatic metastases and the reciprocal …

… IL-6–STAT3 signalling and the subsequent production of SAA, which alters the immune and
fibrotic microenvironment of the liver to establish a pro-metastatic niche (Extended Data Fig. …

… The pathological hallmark of liver fibrosis is the excessive accumulation of extracellular …
the liver parenchyma. Insufficient treatment of underlying liver disease causes progressive liver …

… Consequently, the hepatic immune response to signals … , the immune tolerant features of
the liver can be hijacked by cancer cells to enable their survival and local expansion in the liver. …

… immunity. In this study, we investigated … as the role of T cell activation in the establishment
of liver Trm cell populations. We also investigated the size of the Trm cell niche in the liver by …

… The liver parenchyma is rich in cells of the innate immune system, potentially posing an
obstacle to cancer cells. Particularly macrophages are highly abundant. In rodent …

… the studies on the premetastatic niche in the liver were not always as clearly defined. In respect
to liver metastasis, two of the … Suppression of the immune response in the liver by MDSCs …

… including immune, endothelial and mesenchymal cells spatially located within areas of
scarring, termed the fibrotic niche. Despite progress in our understanding of liver fibrogenesis …