Spatiotemporal immune landscape of colorectal cancer liver metastasis at single-cell level
Y Wu, S Yang, J Ma, Z Chen, G Song, D Rao, Y Cheng… - Cancer discovery, 2022 - AACR
… Our work described the immune evolution of metastasis and uncovered the black box of
how … C, Schematic diagram depicting the unique dynamics of protumor niche in CRLM upon …
how … C, Schematic diagram depicting the unique dynamics of protumor niche in CRLM upon …
Immune escape mechanisms in colorectal cancer pathogenesis and liver metastasis
M Pancione, G Giordano, A Remo… - Journal of …, 2014 - Wiley Online Library
… account the recent accomplishments in the field of immune … , we propose that the evasion of
the immune surveillance and … could be viewed as the evolution of the cancer niche in which (…
the immune surveillance and … could be viewed as the evolution of the cancer niche in which (…
Liver natural killer cells: subsets and roles in liver immunity
H Peng, E Wisse, Z Tian - Cellular & molecular immunology, 2016 - nature.com
… By applying this technique, ‘pit cells,’ which are now known to be the NK cells of rat liver,
were discovered the year after the initial identification of NK cells; this report was …
were discovered the year after the initial identification of NK cells; this report was …
IL-6 drives niche formation in pancreatic cancer liver metastasis
H Thomas - Nature Reviews Gastroenterology & Hepatology, 2019 - nature.com
… that the liver can form a pro-metastatic niche to support metastasis. However, the mechanisms
underlying the formation of this niche … that genes involved in immune-related processes, …
underlying the formation of this niche … that genes involved in immune-related processes, …
Innate immune cells as homeostatic regulators of the hematopoietic niche
… the innate immune system, macrophages and neutrophils, regulate the function of the
hematopoietic niche … niches in fetal liver, red pulp of the spleen and adult bone marrow [46]. These …
hematopoietic niche … niches in fetal liver, red pulp of the spleen and adult bone marrow [46]. These …
Peritoneal GATA6+ macrophage drives hepatic immunopathogenesis and maintains the Treg cell niche in the liver
H Chang, Y Ni, C Shen, C Li, K He, X Zhu, L Chen… - …, 2022 - Wiley Online Library
… the liver. Our findings offer mechanistic insights into peritoneal macrophages as mediators in
the liver immunopathologic microenvironment, and the … roles in the development of immune-…
the liver immunopathologic microenvironment, and the … roles in the development of immune-…
Hypoxia-inducible factors and innate immunity in liver cancer
VWH Yuen, CCL Wong - The Journal of clinical …, 2020 - Am Soc Clin Investig
… Pathogens and toxic agents are cleared rapidly by the innate immune cells in the liver. …
primary cancer and metastatic niches. At the primary liver cancer niche, the LOX family increases …
primary cancer and metastatic niches. At the primary liver cancer niche, the LOX family increases …
Partial hepatectomy accelerates colorectal metastasis by priming an inflammatory premetastatic niche in the liver
J Luenstedt, F Hoping, R Feuerstein… - Frontiers in …, 2024 - frontiersin.org
… changes in the immune cell … the transcriptional profile of the healthy liver tissue via qPCR,
we found a significant induction of several genes associated with the premetastatic niche in the …
we found a significant induction of several genes associated with the premetastatic niche in the …
Susceptibility to infections during acute liver injury depends on transient disruption of liver macrophage niche
… Kupffer cells are the primary liver resident immune cell responsible for the … To better
understand the biology of the KC disappearance in liver-specific niches during ALI, we investigate …
understand the biology of the KC disappearance in liver-specific niches during ALI, we investigate …
The liver cancer immune microenvironment: Therapeutic implications for hepatocellular carcinoma
R Donne, A Lujambio - Hepatology, 2023 - journals.lww.com
… about the role of the liver TME on HCC tumorigenesis. Additionally, we summarize the current
… , TME fuels the growth of cancer cells and forms a safe niche for them to counterbalance …
… , TME fuels the growth of cancer cells and forms a safe niche for them to counterbalance …