Spatiotemporal immune landscape of colorectal cancer liver metastasis at single-cell level

Y Wu, S Yang, J Ma, Z Chen, G Song, D Rao, Y Cheng… - Cancer discovery, 2022 - AACR
… Our work described the immune evolution of metastasis and uncovered the black box of
how … C, Schematic diagram depicting the unique dynamics of protumor niche in CRLM upon …

Immune escape mechanisms in colorectal cancer pathogenesis and liver metastasis

M Pancione, G Giordano, A Remo… - Journal of …, 2014 - Wiley Online Library
… account the recent accomplishments in the field of immune … , we propose that the evasion of
the immune surveillance and … could be viewed as the evolution of the cancer niche in which (…

Liver natural killer cells: subsets and roles in liver immunity

H Peng, E Wisse, Z Tian - Cellular & molecular immunology, 2016 - nature.com
… By applying this technique, ‘pit cells,’ which are now known to be the NK cells of rat liver,
were discovered the year after the initial identification of NK cells; this report was …

IL-6 drives niche formation in pancreatic cancer liver metastasis

H Thomas - Nature Reviews Gastroenterology & Hepatology, 2019 - nature.com
… that the liver can form a pro-metastatic niche to support metastasis. However, the mechanisms
underlying the formation of this niche … that genes involved in immune-related processes, …

Innate immune cells as homeostatic regulators of the hematopoietic niche

M Casanova-Acebes, N A-González, LA Weiss… - International journal of …, 2014 - Springer
the innate immune system, macrophages and neutrophils, regulate the function of the
hematopoietic nicheniches in fetal liver, red pulp of the spleen and adult bone marrow [46]. These …

Peritoneal GATA6+ macrophage drives hepatic immunopathogenesis and maintains the Treg cell niche in the liver

H Chang, Y Ni, C Shen, C Li, K He, X Zhu, L Chen… - …, 2022 - Wiley Online Library
the liver. Our findings offer mechanistic insights into peritoneal macrophages as mediators in
the liver immunopathologic microenvironment, and the … roles in the development of immune-…

Hypoxia-inducible factors and innate immunity in liver cancer

VWH Yuen, CCL Wong - The Journal of clinical …, 2020 - Am Soc Clin Investig
… Pathogens and toxic agents are cleared rapidly by the innate immune cells in the liver. …
primary cancer and metastatic niches. At the primary liver cancer niche, the LOX family increases …

Partial hepatectomy accelerates colorectal metastasis by priming an inflammatory premetastatic niche in the liver

J Luenstedt, F Hoping, R Feuerstein… - Frontiers in …, 2024 - frontiersin.org
… changes in the immune cell … the transcriptional profile of the healthy liver tissue via qPCR,
we found a significant induction of several genes associated with the premetastatic niche in the

Susceptibility to infections during acute liver injury depends on transient disruption of liver macrophage niche

ME Lopes, BN Nakagaki, MS Mattos… - Frontiers in …, 2022 - frontiersin.org
… Kupffer cells are the primary liver resident immune cell responsible for the … To better
understand the biology of the KC disappearance in liver-specific niches during ALI, we investigate …

The liver cancer immune microenvironment: Therapeutic implications for hepatocellular carcinoma

R Donne, A Lujambio - Hepatology, 2023 - journals.lww.com
… about the role of the liver TME on HCC tumorigenesis. Additionally, we summarize the current
… , TME fuels the growth of cancer cells and forms a safe niche for them to counterbalance …