Research has established policing as one of the most stressful occupations and that work-induced strain can lead to various criminal and negative outcomes. This study extends existing literature in criminology and criminal justice by applying general strain theory to police stress. This study examines the influence of prior strain—namely, child abuse and interparental violence—on officer critical incident strain, psychological–physiological stress responses, and officer-on-officer aggression. Data analyzed the stress responses of 1,104 police officers from the Police Stress and Domestic Violence in Police Families in Baltimore, Maryland, and results show that prior strain events influence respondents in three key ways. First, those reporting exposure to childhood strain had higher work-related strain scores. Second, youthful strain events and work-related critical incident strain are associated with increased stress. Finally, child abuse exposure and critical incident strain increases the odds of officer-on-officer violence among participants. The sample offers several important implications for strain theory because it includes only adult respondents and offers some degree of control for serious adolescent delinquency.