The insulin-like growth factors and feto-placental growth
AL Fowden - Placenta, 2003 - Elsevier
The insulin-like growth factors, IGF-I and IGF-II, have an important role in fetoplacental
growth throughout gestation. They have metabolic, mitogenic and differentiative actions in a
wide range of fetal tissues including the placenta. Both Igf1and Igf2genes are expressed in
fetal tissues. Expression of the Igf2gene is more abundant than Igf1 gene expression during
mid to late gestation. Both IGF's are also present in the fetal circulations with 3-10 fold higher
levels of IGF-II than IGF-1 during late gestation. Expression of the Igfgenes is …
growth throughout gestation. They have metabolic, mitogenic and differentiative actions in a
wide range of fetal tissues including the placenta. Both Igf1and Igf2genes are expressed in
fetal tissues. Expression of the Igf2gene is more abundant than Igf1 gene expression during
mid to late gestation. Both IGF's are also present in the fetal circulations with 3-10 fold higher
levels of IGF-II than IGF-1 during late gestation. Expression of the Igfgenes is …
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