Cryptococcus neoformans is a fungal pathogen with worldwide distribution. Serological
studies of human populations show a high prevalence of human infection, which rarely
progresses to disease in immunocompetent hosts. However, decreased host immunity
places individuals at high risk for cryptococcal disease. The disease can result from acute
infection or reactivation of latent infection, in which yeasts within granulomas and host
macrophages emerge to cause disease. In this review, we summarize what is known about …