The purpose of this paper is to analyze the relationship between quality in work factors (QWF) and work engagement (WE) with a mediating role of job satisfaction (JS). A quantitative cross-sectional methodology was used. The sample consisted of 234 bank employees. Data were analyzed with technique structural equation modeling. Results revealed that JS is a total mediator between QWF and WE. The evidence indicates that QWF is an antecedent of WE in the banking sector, but engagement will be increased when banking employees as well are satisfied with their jobs. The overall level of JS and WE was high because bank employees perceive quality on responsibility, feedback, wage, and social support as work factors. This study presents a scope of results limited to the north-central region of Mexico.