The mesenchymal stromal cells dilemma—does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease …
J Galipeau - Cytotherapy, 2013 - Elsevier
The use of cryopreserved unmatched allogeneic mesenchymal stromal cells (MSCs) for
treatment of steroid-resistant graft-versus-host disease has become medical practice in
many European jurisdictions. The enthusiasm for use of MSCs in transplantation medicine
builds on compelling phase II clinical trial data published by European collaborative groups
in the past few years. Notwithstanding, it was reported in 2009 that a large multicenter phase
III clinical trial (NCT00366145) conducted in the USA examining the use of an industrial …
treatment of steroid-resistant graft-versus-host disease has become medical practice in
many European jurisdictions. The enthusiasm for use of MSCs in transplantation medicine
builds on compelling phase II clinical trial data published by European collaborative groups
in the past few years. Notwithstanding, it was reported in 2009 that a large multicenter phase
III clinical trial (NCT00366145) conducted in the USA examining the use of an industrial …
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