The metabolism of menadione (2-methyl-1, 4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.
The cytotoxic effects of many quinones are thought to be mediated through their one-
electron reduction to semiquinone radicals, which subsequently enter redox cycles with
molecular oxygen to produce active oxygen species and oxidative stress. The two-electron
reduction of quinones to diols, mediated by DT-diaphorase (NAD (P) H:(quinone-acceptor)
oxidoreductase), may therefore represent a detoxifying pathway which protects the cell from
the formation of these reactive intermediates. By using menadione (2-methyl-1, 4 …
electron reduction to semiquinone radicals, which subsequently enter redox cycles with
molecular oxygen to produce active oxygen species and oxidative stress. The two-electron
reduction of quinones to diols, mediated by DT-diaphorase (NAD (P) H:(quinone-acceptor)
oxidoreductase), may therefore represent a detoxifying pathway which protects the cell from
the formation of these reactive intermediates. By using menadione (2-methyl-1, 4 …
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