Modern science be} ins to understand pleasure as a potential component of salu to} enesis. Thereby, pleasure is described as a state or feelin} of happiness and satisfaction resultin} from an experience that one enjoys. We examine the neuro biolo} ical factors underlyin} reward processes and pleasure phenomena. Further, health implications related to pleasurable activities are analyzed. With re} ard to possible ne} ative effects of pleasure, we focus on addiction and motivational tox icity. Pleasure can serve co} nition, productivity and health, but simultaneously promotes addiction and other ne} ative behaviors, ie, motivational toxicity. It is a complex neurobiolo} ical phenomenon, relyin} on reward circuitry or limbic activ ity. These processes involve dopaminer} ic si} nalin}. Moreover, endorphin and endo} enous morphiner} ic mechanisms may play a role. Natural rewardin} activ ities are necessary for survival and appetitive motivation, usually} overnin} ben eficial biolo} ical behaviors like eatin}, sex and reproduction. Social contacts can further facilitate the positive effects exerted by pleasurable experiences. How ever, artificial stimulants can be detrimental, since yexibility and normal control of behavior are deteriorated. Additionally, addictive dru} s are capable of directly actin} on reward pathways. Thus, the concrete outcome of pleasant experiences may be a question of dose. Moderate pleasurable experiences are able to enhance biolo} ical yexibility and health. Hence, pleasure can be a resistance resource or may serve saluto} enesis. Natural rewards are mediated by sensory or} an stim ulation, thereby exhibitin} a potential association with complementary medi cal approaches. Trust and belief can be part of a self healin} potential connected with rewardin} stimuli. Further, the placebo response physiolo} ically resembles pleasure phenomena, since both involve brain½s reward circuitry stimulation and subjective feelin} s of well bein}. Pleasurable activities can stimulate personal} rowth and may help to induce healthy behavioral chan} es, includin} stress man a} ement. However, more research is needed to better understand the nature, neurobiolo} y and maybe dan} erous aspects of pleasure. Also, a possible involve ment of endo} enous morphiner} ic si} nalin} has to be studied further.