The novel 5-lipoxygenase inhibitor ABT-761 attenuates cerebral vasospasm in a rabbit model of subarachnoid hemorrhage
MD Barbosa, AS Arthur, RH Louis, T MacDonald… - …, 2001 - journals.lww.com
OBJECTIVE: Eicosanoids have been implicated in the pathogenesis of cerebral vasospasm
after subarachnoid hemorrhage (SAH). Leukotrienes, 5-hydroxyperoxyeicosatetraenoic
acid, and 5-hydroxyeicosatetraenoic acid are part of this group of substances, resulting from
the 5-lipoxygenase activity on arachidonic acid metabolism. This study examined the effects
of ABT-761, a new 5-lipoxygenase inhibitor, on cerebral vasospasm in an in vivo rabbit
model of SAH. METHODS: A total of 48 rabbits were assigned to one of six groups: SAH+ …
after subarachnoid hemorrhage (SAH). Leukotrienes, 5-hydroxyperoxyeicosatetraenoic
acid, and 5-hydroxyeicosatetraenoic acid are part of this group of substances, resulting from
the 5-lipoxygenase activity on arachidonic acid metabolism. This study examined the effects
of ABT-761, a new 5-lipoxygenase inhibitor, on cerebral vasospasm in an in vivo rabbit
model of SAH. METHODS: A total of 48 rabbits were assigned to one of six groups: SAH+ …
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