We evaluated the effect of overexpressing antioxidant enzymes on the lifespans of
transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase,
or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide
dismutase (MnSOD). Our results show that the overexpression of these major antioxidant
enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic
and mitochondrial compartments, is insufficient to extend lifespan in mice.

The overexpression of major antioxidant enzymes does not extend the lifespan of mice |
CiNii Research … The overexpression of major antioxidant enzymes does not extend the
lifespan of mice …