The projection targets of medium spiny neurons govern cocaine-evoked synaptic plasticity in the nucleus accumbens
We examine synaptic connectivity and cocaine-evoked plasticity at specific networks within
the nucleus accumbens (NAc). We identify distinct subpopulations of D1+ medium spiny
neurons (MSNs) that project to either the ventral pallidum (D1+ VP) or the ventral tegmental
area (D1+ VTA). We show that inputs from the ventral hippocampus (vHPC), but not the
basolateral amygdala (BLA), are initially biased onto D1+ VTA MSNs. However, repeated
cocaine exposure eliminates the bias of vHPC inputs onto D1+ VTA MSNs, while …
the nucleus accumbens (NAc). We identify distinct subpopulations of D1+ medium spiny
neurons (MSNs) that project to either the ventral pallidum (D1+ VP) or the ventral tegmental
area (D1+ VTA). We show that inputs from the ventral hippocampus (vHPC), but not the
basolateral amygdala (BLA), are initially biased onto D1+ VTA MSNs. However, repeated
cocaine exposure eliminates the bias of vHPC inputs onto D1+ VTA MSNs, while …
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