The CXC chemokine family is a pleiotropic family of cytokines that are involved in promoting
the trafficking of various leukocytes, in regulating angiogenesis and vascular remodeling,
and in promoting the mobilization and trafficking of mesenchymal progenitor cells such as
fibrocytes. These functions of CXC chemokines are important in the pathogenesis of
pulmonary fibrosis and other fibroproliferative disorders. In this Review, we discuss the
biology of CXC chemokine family members, specifically as it relates to their role in regulating …

The inflammatory process in systemic lupus erythematosus (SLE) affects many organs
including the lungs. CXC chemokines are suggested to play an important role in the
pathogenesis of SLE and pulmonary fibrosis. To estimate the concentrations of CXCL9,
CXCL10, CXCL11 in bronchoalveolar lavage fluid (BALF) of patients with and without
pulmonary involvements of SLE to evaluate CXC chemokines role in the pathogenesis of
pulmonary fibrosis in SLE. Twenty-six SLE patients and 31 healthy controls were evaluated …