One compelling challenge in the therapy of epilepsy is to develop anti-epileptogenic drugs
with an impact on the disease progression. The search for novel targets has focused
recently on brain inflammation since this phenomenon appears to be an integral part of the
diseased hyperexcitable brain tissue from which spontaneous and recurrent seizures
originate. Although the contribution of specific proinflammatory pathways to the mechanism
of ictogenesis in epileptic tissue has been demonstrated in experimental models, the role of …

Epilepsy is a chronic neurological disorder that has an extensive impact on a patient's life.
Accumulating evidence has suggested that inflammation participates in the progression of
spontaneous and recurrent seizures. Pro-convulsant incidences can stimulate immune cells,
augment the release of pro-inflammatory cytokines, elicit neuronal excitation as well as
blood-brain barrier (BBB) dysfunction, and finally trigger the generation or recurrence of
seizures. Understanding the pathogenic roles of inflammatory mediators, including …