The role of neurotrophic factors in genesis and maintenance of mechanical hypernociception after brachial plexus avulsion in mice
Neurotrophic factors (NTFs), namely nerve growth factor (NGF), glial cell line-derived
neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3
(NT-3), have recently emerged as a new exciting class of potential targets for the
development of drugs to treat chronic pain. We have recently reported that brachial plexus
avulsion (BPA) results in a marked and long-lasting mechanical hypernociception in
rodents. Here we demonstrate that antibodies against NGF, NT-3, GDNF and BDNF were …
neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3
(NT-3), have recently emerged as a new exciting class of potential targets for the
development of drugs to treat chronic pain. We have recently reported that brachial plexus
avulsion (BPA) results in a marked and long-lasting mechanical hypernociception in
rodents. Here we demonstrate that antibodies against NGF, NT-3, GDNF and BDNF were …
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