The sciatic nerve cuffing model of neuropathic pain in mice

I Yalcin, S Megat, F Barthas, E Waltisperger… - JoVE (Journal of …, 2014 - jove.com
Neuropathic pain arises as a consequence of a lesion or a disease affecting the
somatosensory system. This syndrome results from maladaptive changes in injured sensory
neurons and along the entire nociceptive pathway within the central nervous system. It is
usually chronic and challenging to treat. In order to study neuropathic pain and its
treatments, different models have been developed in rodents. These models derive from
known etiologies, thus reproducing peripheral nerve injuries, central injuries, and metabolic …
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