A large multiparametric MRI study has been undertaken to evaluate anatomical patterns of
basal ganglia, white matter and cortical grey matter involvement in ALS. Unaffected brain
regions are mapped in patients with significant disability. Multiple white matter diffusivity
measures, cortical grey matter density alterations, basal ganglia volumes and subcortical
grey matter atrophy patterns are evaluated. Results demonstrated a strikingly selective
anatomical vulnerability pattern in ALS that preferentially affects specific grey matter …