The sites of neurotoxicity in alpha-cobratoxin.
BM Martin, BA Chibber, A Maelicke - Journal of Biological Chemistry, 1983 - ASBMB
We have chemically modified groups of amino acids in the sequence of alpha-cobratoxin
and have studied the derivatives as to their affinity of binding to the acetylcholine receptor
protein from Torpedo marmorata.(i) The toxin derivatives which were fully modified at lysine
(penta-epsilon-N, N-dimethyl lysine; penta-epsilon-N-acetyl lysine), arginine (penta-N7, N8-
(1, 2-dihydroxycyclohex-1, 2-ylene arginine), and tyrosine (mononitrotyrosine) all had
significant remaining toxicity and affinity of binding.(ii) The" extra" disulfide of alpha …
and have studied the derivatives as to their affinity of binding to the acetylcholine receptor
protein from Torpedo marmorata.(i) The toxin derivatives which were fully modified at lysine
(penta-epsilon-N, N-dimethyl lysine; penta-epsilon-N-acetyl lysine), arginine (penta-N7, N8-
(1, 2-dihydroxycyclohex-1, 2-ylene arginine), and tyrosine (mononitrotyrosine) all had
significant remaining toxicity and affinity of binding.(ii) The" extra" disulfide of alpha …
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