The structure of the periplasmic ligand-binding domain of the sensor kinase CitA reveals the first extracellular PAS domain
The integral membrane sensor kinase CitA of Klebsiella pneumoniae is part of a two-
component signal transduction system that regulates the transport and metabolism of citrate
in response to its environmental concentration. Two-component systems are widely used by
bacteria for such adaptive processes, but the stereochemistry of periplasmic ligand binding
and the mechanism of signal transduction across the membrane remain poorly understood.
The crystal structure of the CitAP periplasmic sensor domain in complex with citrate reveals …
component signal transduction system that regulates the transport and metabolism of citrate
in response to its environmental concentration. Two-component systems are widely used by
bacteria for such adaptive processes, but the stereochemistry of periplasmic ligand binding
and the mechanism of signal transduction across the membrane remain poorly understood.
The crystal structure of the CitAP periplasmic sensor domain in complex with citrate reveals …
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