The use of hydrogen sulfide donor in cardiac control during low doses of ionizing radiation (Experimental study)
Southeastern European Medical Journal: SEEMEDJ, 2018•hrcak.srce.hr
Aim: To analyze the influence of the hydrogen sulfide donor NaHS on the cardiac control in
rats during low doses of ionizing radiation and characterize the predictors of imbalance in
autonomic nervous system activities. Methods: Adult male rats were treated once with NaHS
7.4 mg/kg, ip or vehicle (saline), without and with total body irradiation (TBI). The irradiation
of animals in experimental groups was single-fractional, total, with total absorbed dose–2
Gy. Heart rate variability (HRV) was recorded in rats after 30 minutes with NaHS pre …
rats during low doses of ionizing radiation and characterize the predictors of imbalance in
autonomic nervous system activities. Methods: Adult male rats were treated once with NaHS
7.4 mg/kg, ip or vehicle (saline), without and with total body irradiation (TBI). The irradiation
of animals in experimental groups was single-fractional, total, with total absorbed dose–2
Gy. Heart rate variability (HRV) was recorded in rats after 30 minutes with NaHS pre …
Sažetak
Aim: To analyze the influence of the hydrogen sulfide donor NaHS on the cardiac control in rats during low doses of ionizing radiation and characterize the predictors of imbalance in autonomic nervous system activities.
Methods: Adult male rats were treated once with NaHS 7.4 mg/kg, ip or vehicle (saline), without and with total body irradiation (TBI). The irradiation of animals in experimental groups was single-fractional, total, with total absorbed dose–2 Gy. Heart rate variability (HRV) was recorded in rats after 30 minutes with NaHS pre-treatment, 24 h of TBI exposure and NaHS and TBI combination.
Results: HRV analysis revealed that low doses of radiation cause cardiac autonomic dysfunction. TBI rats exhibited signs of activation of sympathetic nervous system, while NaHS-treated rats showed mobilization of all parts of regulatory systems with predominant activation of the parasympathetic nervous system (PSNS). Overall, these results indicate that NaHS is involved in cardiac control and decreases sensitivity to low doses of radiation.
Conclusion: The gaseous messenger H2S under conditions of radiation modulates adaptive processes, acting as a regulator for imbalance of autonomic nervous system and may serve as a novel cardioprotective agent for ANS imbalance.
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