Osteoarthritis (OA), degeneration of cartilage associated with aging, lifestyle, and trauma, is
one of the most common diseases that leads to lower quality of life and socioeconomic
burden in the United States. Clinically, OA is initially managed by non-steroidal anti-
inflammatory drugs, but eventually requires surgical intervention to reduce pain and
increase function. Cartilage is a mechanotransductive tissue and requires a mechanical
stimulus to sustain its mechanical and physiologic properties. Low-intensity pulsed …