… than 3 hours after the onset of symptoms have not been established. We tested the efficacy
and safety of alteplase administered between 3 and 4.5 hours after the onset of a stroke. …

… Conclusion:Our study suggests that patients with acute ischemic stroke may be successfully
treated with intravenous tPA in the 3–4.5-hour treatment window, but cautions that later time …

… acute ischemic stroke with alteplase has not been established. Purpose:The objective of …
of IV alteplase thrombolysis within a 6-hour time frame following ischemic stroke. Methods: …

… between the control and IV tPA groups for the 3- to 4.5-hour time window. This analysis …
IV tPA in the extended time window but likely not past 4.5 hours. Third International Stroke …

… –4.5 hours after the onset of stroke symptoms in Chinese patients is limited. We sought to …
benefit from thrombolysis with alteplase between 3 and 4.5 hours after the onset of stroke …

… patients within 3 hours of stroke onset, we extended the time to thrombolysis to 4.5 hours.[ 5
11 … points of TNK and alteplase within 3 hours and 3 – 4.5 hours showed comparable results. …

… acute ischaemic stroke currently recommend extending the use of alteplase up to 4.5 hours
after stroke … trial to have reported benefit from use of alteplase 3–4.5 hours after stroke onset. …

… Thrombolysis should be initiated within 4·5 h after onset of ischaemic stroke, although
every effort should be made to treat patients as early as possible after symptom onset. …

… alteplase in patients 3–4.5 hours after ischemic stroke onset. … patients treated with alteplase
3–4.5 hours after stroke onset with … This trial found that patients treated with alteplase were …

… Meta-analysis of randomized controlled trials (n > 100) of patients treated with tPA for
acute ischemic stroke between 3 and 4.5 h. A PubMed search and authors' knowledge of the …