Impairments of cellular plasticity appear to underlie the pathophysiology of major
depression. Recently, elevated levels of phosphorylated AMPA receptor were implicated in
the antidepressant effect of various drugs. Here, we investigated the effects of an
antidepressant, Tianeptine, on synaptic function and GluA1 phosphorylation using murine
hippocampal slices and in vivo single-unit recordings. Tianeptine, but not imipramine,
increased AMPA receptor-mediated neuronal responses both in vitro and in vivo, in a …