Time-course microarrays reveal early activation of the immune transcriptome and adipokine dysregulation leads to fibrosis in visceral adipose depots during diet …
EY Kwon, SK Shin, YY Cho, UJ Jung, E Kim, T Park… - BMC genomics, 2012 - Springer
Background Visceral white adipose tissue (WAT) hypertrophy, adipokine production,
inflammation and fibrosis are strongly associated with obesity, but the time-course of these
changes in-vivo are not fully understood. Therefore, the aim of this study was to establish the
time-course of changes in adipocyte morphology, adipokines and the global transcriptional
landscape in visceral WAT during the development of diet-induced obesity. Results C57BL/6
J mice were fed a high-fat diet (HFD) or normal diet (ND) and sacrificed at 8 time-points over …
inflammation and fibrosis are strongly associated with obesity, but the time-course of these
changes in-vivo are not fully understood. Therefore, the aim of this study was to establish the
time-course of changes in adipocyte morphology, adipokines and the global transcriptional
landscape in visceral WAT during the development of diet-induced obesity. Results C57BL/6
J mice were fed a high-fat diet (HFD) or normal diet (ND) and sacrificed at 8 time-points over …
Time-course microarrays reveal early activation of the immune transcriptome and adipokine dysregulation leads to fibrosis in visceral adipose depots during diet …
KEY Kwon EunYoung, SSK Shin SuKyung… - 2012 - cabidigitallibrary.org
Background: Visceral white adipose tissue (WAT) hypertrophy, adipokine production,
inflammation and fibrosis are strongly associated with obesity, but the time-course of these
changes in-vivo are not fully understood. Therefore, the aim of this study was to establish the
time-course of changes in adipocyte morphology, adipokines and the global transcriptional
landscape in visceral WAT during the development of diet-induced obesity. Results:
C57BL/6J mice were fed a high-fat diet (HFD) or normal diet (ND) and sacrificed at 8 time …
inflammation and fibrosis are strongly associated with obesity, but the time-course of these
changes in-vivo are not fully understood. Therefore, the aim of this study was to establish the
time-course of changes in adipocyte morphology, adipokines and the global transcriptional
landscape in visceral WAT during the development of diet-induced obesity. Results:
C57BL/6J mice were fed a high-fat diet (HFD) or normal diet (ND) and sacrificed at 8 time …
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