Tissue distribution of berberine and its metabolites after oral administration in rats
XS Tan, JY Ma, R Feng, C Ma, WJ Chen, YP Sun, J Fu… - PloS one, 2013 - journals.plos.org
Berberine (BBR) has been confirmed to have multiple bioactivities in clinic, such as
cholesterol-lowering, anti-diabetes, cardiovascular protection and anti-inflammation.
However, BBR's plasma level is very low; it cannot explain its pharmacological effects in
patients. We consider that the in vivo distribution of BBR as well as of its bioactive
metabolites might provide part of the explanation for this question. In this study, liquid
chromatography coupled to ion trap time-of-flight mass spectrometry (LC/MSn-IT-TOF) as …
cholesterol-lowering, anti-diabetes, cardiovascular protection and anti-inflammation.
However, BBR's plasma level is very low; it cannot explain its pharmacological effects in
patients. We consider that the in vivo distribution of BBR as well as of its bioactive
metabolites might provide part of the explanation for this question. In this study, liquid
chromatography coupled to ion trap time-of-flight mass spectrometry (LC/MSn-IT-TOF) as …
Tissue distribution of berberine and its metabolites after oral administration in rats.
TXS Tan XiangShan, MJY Ma JingYi, FR Feng Ru… - 2013 - cabidigitallibrary.org
Berberine (BBR) has been confirmed to have multiple bioactivities in clinic, such as
cholesterol-lowering, anti-diabetes, cardiovascular protection and anti-inflammation.
However, BBR's plasma level is very low; it cannot explain its pharmacological effects in
patients. We consider that the in vivo distribution of BBR as well as of its bioactive
metabolites might provide part of the explanation for this question. In this study, liquid
chromatography coupled to ion trap time-of-flight mass spectrometry (LC/MSn-IT-TOF) as …
cholesterol-lowering, anti-diabetes, cardiovascular protection and anti-inflammation.
However, BBR's plasma level is very low; it cannot explain its pharmacological effects in
patients. We consider that the in vivo distribution of BBR as well as of its bioactive
metabolites might provide part of the explanation for this question. In this study, liquid
chromatography coupled to ion trap time-of-flight mass spectrometry (LC/MSn-IT-TOF) as …
以上显示的是最相近的搜索结果。 查看全部搜索结果