Tracking a Hospital Outbreak of Carbapenem-Resistant Klebsiella pneumoniae with Whole-Genome Sequencing
ES Snitkin, AM Zelazny, PJ Thomas, F Stock… - Science translational …, 2012 - science.org
The Gram-negative bacteria Klebsiella pneumoniae is a major cause of nosocomial
infections, primarily among immunocompromised patients. The emergence of strains
resistant to carbapenems has left few treatment options, making infection containment
critical. In 2011, the US National Institutes of Health Clinical Center experienced an outbreak
of carbapenem-resistant K. pneumoniae that affected 18 patients, 11 of whom died. Whole-
genome sequencing was performed on K. pneumoniae isolates to gain insight into why the …
infections, primarily among immunocompromised patients. The emergence of strains
resistant to carbapenems has left few treatment options, making infection containment
critical. In 2011, the US National Institutes of Health Clinical Center experienced an outbreak
of carbapenem-resistant K. pneumoniae that affected 18 patients, 11 of whom died. Whole-
genome sequencing was performed on K. pneumoniae isolates to gain insight into why the …
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