Bixa orellana L., popularly known as “urucum,” has been used by indigenous communities
in Brazil and other tropical countries for several biological applications, which indicates its
potential use as an active ingredient in pharmaceutical products. The aim of this work was to
report the main evidence found in the literature, concerning the ethnopharmacology, the
biological activity, and the phytochemistry studies related to Bixa orellana L. Therefore, this
work comprises a systematic review about the use of Bixa orellana in the American continent …