Trans-omics analysis of insulin action reveals a cell growth subnetwork which co-regulates anabolic processes
Insulin signaling promotes anabolic metabolism to regulate cell growth through multi-omic
interactions. To obtain a comprehensive view of the cellular responses to insulin, we
constructed a trans-omic network of insulin action in Drosophila cells that involves the
integration of multi-omic data sets. In this network, 14 transcription factors, including Myc,
coordinately upregulate the gene expression of anabolic processes such as nucleotide
synthesis, transcription, and translation, consistent with decreases in metabolites such as …
interactions. To obtain a comprehensive view of the cellular responses to insulin, we
constructed a trans-omic network of insulin action in Drosophila cells that involves the
integration of multi-omic data sets. In this network, 14 transcription factors, including Myc,
coordinately upregulate the gene expression of anabolic processes such as nucleotide
synthesis, transcription, and translation, consistent with decreases in metabolites such as …
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