The placenta is a transient organ that plays a critical role in sustaining pregnancy and
supporting fetal growth and nutrition. The placental epithelium is comprised of trophoblast
cells. Trophoblast cells are the first cell type to differentiate during embryogenesis and
ultimately diversify into a heterogeneous population of cells specializing in distinct functions
essential for placentation. The emergence of the trophoblast lineage and subsequent
specialization into distinct trophoblast sublineages is tightly regulated by transcription …