Transcription of a 5'extended mRNA isoform directs dynamic chromatin changes and interference of a downstream promoter
Cell differentiation programs require dynamic regulation of gene expression. During meiotic
prophase in Saccharomyces cerevisiae, expression of the kinetochore complex subunit
Ndc80 is downregulated by a 5'extended long undecoded NDC80 transcript isoform. Here
we demonstrate a transcriptional interference mechanism that is responsible for inhibiting
expression of the coding NDC80 mRNA isoform. Transcription from a distal NDC80
promoter directs Set1-dependent histone H3K4 dimethylation and Set2-dependent H3K36 …
prophase in Saccharomyces cerevisiae, expression of the kinetochore complex subunit
Ndc80 is downregulated by a 5'extended long undecoded NDC80 transcript isoform. Here
we demonstrate a transcriptional interference mechanism that is responsible for inhibiting
expression of the coding NDC80 mRNA isoform. Transcription from a distal NDC80
promoter directs Set1-dependent histone H3K4 dimethylation and Set2-dependent H3K36 …
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