Transforming growth factor β1 decreases cholesterol supply to mitochondria via repression of steroidogenic acute regulatory protein expression
C Brand, N Cherradi, G Defaye, A Chinn… - Journal of Biological …, 1998 - ASBMB
Transforming growth factor-βs (TGF-βs) constitute a family of dimeric proteins that affect
growth and differentiation of many cell types. TGF-β 1 has also been proposed to be an
autocrine regulator of adrenocortical steroidogenesis, acting mainly by decreasing the
expression of cytochrome P450c17. Here, we demonstrate that TGF-β 1 has a second target
in bovine adrenocortical cells, namely the steroidogenic acute regulatory protein (StAR).
Indeed, supplying cells with steroid precursors revealed that TGF-β 1 inhibited two steps in …
growth and differentiation of many cell types. TGF-β 1 has also been proposed to be an
autocrine regulator of adrenocortical steroidogenesis, acting mainly by decreasing the
expression of cytochrome P450c17. Here, we demonstrate that TGF-β 1 has a second target
in bovine adrenocortical cells, namely the steroidogenic acute regulatory protein (StAR).
Indeed, supplying cells with steroid precursors revealed that TGF-β 1 inhibited two steps in …
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