A network-based analysis of systemic inflammation in humans

…, Inflammation and Host Response to Injury Large Scale … - Nature, 2005 - nature.com
inflammation includes the transient dysregulation of leukocyte bioenergetics and modulation
of translationalsystem tolerance and increased susceptibility to infection in humans. …

An Overview of the Translational Dilemma and the Need for Model-Based Precision Medicine

Y Vodovotz, G An - … Biology Approaches to Acute Inflammation: A …, 2021 - Springer
Translational Systems Biology approach. Furthermore, we suggest that therapy for complex
inflammatory … , involving dynamic reprogramming of inflammation and associated processes. …

Translation control: a multifaceted regulator of inflammatory response

B Mazumder, X Li, S Barik - The Journal of Immunology, 2010 - journals.aai.org
translational control in regulating acute inflammation is evident from emerging studies. It is
obligatory for the cells of the immune system to rapidly activate the inflammatoryTranslational

Systems engineering medicine: engineering the inflammation response to infectious and traumatic challenges

RS Parker, G Clermont - Journal of The Royal Society …, 2010 - royalsocietypublishing.org
Systems medicine, the translational science counterpart to basic science's systems biology,
is the interface at which these tools may be constructed. Rapid initial strides in improving …

Inflammatory mechanisms in tendinopathy–towards translation

NL Millar, GAC Murrell, IB McInnes - Nature reviews rheumatology, 2017 - nature.com
… For clarity and subsequent translational utility… inflammatory responses comprise complex
multi-cellular responses coordinated by groups of mediators operating in a coordinated system

A decade of systems biology

HY Chuang, M Hofree, T Ideker - … cell and developmental biology, 2010 - annualreviews.org
… the translationalsystems biology that are likely to be of particular importance during the
decade to follow: (a) pathway-based biomarkers, (b) global genetic interaction maps, (c) systems

Animal models of kidney inflammation in translational medicine

A Holderied, HJ Anders - Drug Discovery Today: Disease Models, 2014 - Elsevier
… meanwhile implemented numerous novel (biological) drugs in clinical practice; … inflammation
in order to minimize avoidable animal experimentation and to accelerate the translational

Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics

L Wang, A Muneer, L Xie, F Zhang, B Wu, L Mei… - bioRxiv, 2020 - biorxiv.org
translation regulatory axis, G9a activated the translation of … From a systems view, we discovered
the G9a-associated … active G9a promotes the translation of genes that comprise diverse …

Targeting translational control as a novel way to treat inflammatory disease: the emerging role of microRNAs

M Plank, S Maltby, J Mattes… - Clinical & Experimental …, 2013 - Wiley Online Library
… of translational control of inflammatory molecules and pathways may occur. To date, only
a small number of miRNAs has been associated with specific inflammatory diseases and …

[HTML][HTML] … and Translational Physiology: Inflammation and Immunity in Organ System Physiology: Life without TTP: apparent absence of an important anti-inflammatory …

WS Lai, DJ Stumpo, EA Kennington… - American Journal of …, 2013 - ncbi.nlm.nih.gov
… TTP knockout mice exhibit a severe systemic inflammatory syndrome, and they are abnormally
sensitive to innate immune stimuli such as LPS. TTP orthologs have been found in most …