… in critical biological processes. In this review, we summarize systems biology methodologies
such as functional genomics, causality inference, data-driven biological network …

… innate system as a first line of defense against pathogens ( 1 ). However, signaling is sometimes
conflicting and a sustained inflammatory … inflammation. A microvasculature injured by …

… copes with inflammatory stress by changing gene transcription and protein translation by the
… transcriptional, translational and post-translational level based largely on non-β cell studies. …

… in systems biology reflects the increasing importance that integrative initiatives are being
accorded in the biological … , thus enabling the use of systems biology in translational research. …

… metabolic stresses control mRNA translation and how the translational program is linked to
… lead to an inflammatory response, at both the transcriptional and translational levels, that is …

… designed to facilitate the translation of biological and clinical … We in the translational systems
biology community hope that … systems biology communities to aid us in these translational …

… the complex dynamics of the system by studying the properties of its essential dynamic
parts. A central tenet of Translational Systems Biology is that computational models should be …

… , inflammation and immune system-related pathways were identified as leading biological
… Therefore, enhanced activity of inflammation might represent one of the biological pathways …

… between inflammatory compartments to develop a roadmap toward the translational … of
NIH/NHLBI Exploratory Program in Systems Biology. Many of the researchers who are co-…

… of translational systems biology in inflammation have been … We propose a new systems
biology model that captures … which normal and pathological inflammatory responses are elicited. …